Pharmacokinetics of insulin aspart in obesity, renal impairment, or hepatic impairment
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چکیده
منابع مشابه
Pharmacokinetics of tedizolid in subjects with renal or hepatic impairment.
Two open-label, single-dose, parallel-group studies were conducted to characterize the pharmacokinetics of the novel antibacterial tedizolid and the safety of tedizolid phosphate, its prodrug, in renally or hepatically impaired subjects. Tedizolid pharmacokinetics in subjects with severe renal impairment without dialysis support was compared with that of matched control subjects with normal ren...
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BACKGROUND Insulin degludec is a new-generation basal insulin with an ultra-long duration of action. We evaluated the pharmacokinetic properties of insulin degludec in subjects with normal renal function; mild, moderate or severe renal impairment; or end-stage renal disease (ESRD) undergoing hemodialysis. METHODS Thirty subjects (n = 6 per group) received a single subcutaneous dose of 0.4 U/k...
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Tasimelteon is a circadian regulator that resets the master clock in the suprachiasmatic nuclei of the hypothalamus by binding to both melatonin MT1 and MT2 receptors making it a dual melatonin receptor agonist. Tasimelteon has been approved by the United States Food and Drug Administration for the treatment of Non-24-Hour Sleep-Wake Disorder (Non-24). Two prospective, single-center, open-label...
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Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by recurrent abdominal pain and altered bowel movements that is subtyped as predominantly diarrheal (IBS-D), constipating, or mixed/alternating between diarrhea and constipation.1 The global presence of IBS is approximately 11%, with one-third of all IBS cases being IBS-D.2,3 Patients with IBS-D commonly experie...
متن کاملHomocysteine or Renal Impairment
Objective—The purpose of this study was to determine whether adjustment for renal function eliminates the relationship between total plasma homocysteine (tHcy) and vascular risk, assessed by carotid intima medial thickness (CIMT) and flow-mediated dilation (FMD) of the brachial artery. Methods and Results—We used cross-sectional data from 173 stroke patients treated with B-vitamins (folic acid ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2005
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.2005.02476.x